The regulation will become effective on May 1, 2017.
Growing of GM corn, rice and soybean will be banned, while illegal production and sales of GM crops and supply of their seeds will also be prohibited.
The new regulation also bans illegal production, processing, sale and imports of edible GM farm produce or edible farm products that contain GM ingredients. It requires all GM food be sold in a special zone, clearly indicated in stores.
The decision comes after 91.5 percent of responses in a survey in the province in October raised objections to GM crops.
"We support the research and development of transgenetic technology, but we should be cautious in applying the techniques in crop production," said Yao Dawei, director of the provincial legislature.